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Regulation of ILC2s by Brg1 (RNA-seq on ILC2nav ILC2eff)

GSE279668 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/09/17 Platform GPL30215
Summary
The alteration of chromatin status critically dictates the expansion and function of group 2 innate lymphoid cells (ILC2s), which have been shown to play a pathogenic role in allergic lung inflammation. In this study, we use multi-omics approaches to dissect the molecular mechanisms of how Brg1 regulates ILC2s in allergic lung diseases through a cell intrinsic manner. Our data indicate that Brg1 regulates ILC2 properties through orchestrating ILC2 energetic metabolism. These findings are enlightening for the understanding of ILC2-mediated pathogenesis in allergic lung inflammation and highlight Brg1 as a potential therapeutic target.
Published in
Brg1-imprinted chromatin status controls effector and memory group 2 innate lymphoid cell metabolism to exacerbate allergic lung inflammation
Tang J, Sun H, Chang H et al. · The Journal of allergy and clinical immunology 2026 · PMID 40972980 · doi:10.1016/j.jaci.2025.08.029
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Also filed as BioProject PRJNA1174064 and SRA study SRP539097. Searching any of these in the dataset finder brings you back here.

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