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Effect of depletion of FXR on gene expression in islets from FXR knockout mice

GSE279682 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/12 Platform GPL13112
Summary
FXR (Farnesoid X Receptor), also known as Nr1h4, is a transcription factor who is also one of the bile acid receptor has been reported to be widely involved in regulating blood glucose, bile acid, and the apoptosis of hepatocyte. We have been studing the key role of FXR in Type 2 Diabetes, which can regulate the insulin secretion or even the apoptosis of β-cells. Thus,we measured the gene expression in the islets of FXR KO mice. Our data shows the abnormal expressed gene between the FXR KO mice and the Control group, which may be regulated by FXR. It will be significant promotion for the research in mechanism of FXR regulating the insulin secretion and apoptosis of β-cells.
Published in
FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes
Shao L, Kong X, Lv S et al. · Cell death & disease 2024 · PMID 39702527 · doi:10.1038/s41419-024-07302-4
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Also filed as BioProject PRJNA1174076 and SRA study SRP539101. Searching any of these in the dataset finder brings you back here.

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