Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × Ctrl vs 5 × PPF vs 5 × PD-1 vs 5 × ComGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanomaJournal for immunotherapy of cancer · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279924_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1175556 and SRA study SRP539810. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8583423 Ctrl_1 Ctrl
- GSM8583424 Ctrl_2 Ctrl
- GSM8583425 Ctrl_3 Ctrl
- GSM8583426 Ctrl_4 Ctrl
- GSM8583427 Ctrl_5 Ctrl
- GSM8583428 PPF_1 PPF
- GSM8583429 PPF_2 PPF
- GSM8583430 PPF_3 PPF
- GSM8583431 PPF_4 PPF
- GSM8583432 PPF_5 PPF
- GSM8583433 PD-1_1 PD-1
- GSM8583434 PD-1_2 PD-1
- GSM8583435 PD-1_3 PD-1
- GSM8583436 PD-1_4 PD-1
- GSM8583437 PD-1_5 PD-1
- GSM8583438 Com_1 Com
- GSM8583439 Com_2 Com
- GSM8583440 Com_3 Com
- GSM8583441 Com_4 Com
- GSM8583442 Com_5 Com
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- GSE263625 Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases 19 samples shares immunotherapy, melanoma
- GSE280080 Radiotherapy synergizes with AAV-based immunotherapy to program local and systemic antitumor immunity 15 samples shares immunotherapy, synergizes
- GSE231357 Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy 14 samples shares immunotherapy, facilitates
- GSE231355 Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy [kdSdc1_RNAseq] 12 samples shares immunotherapy, facilitates
- GSE215963 Subclonal evolution revealed by single-cell profiles of expressed mutations identifies adaptation mechanisms to immunotherapy in melanoma. 1497 samples shares immunotherapy, melanoma
- GSE292854 Cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma with an immune-excluded phenotype 10 samples shares immunotherapy, melanoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.