Radiotherapy synergizes with AAV-based immunotherapy to program local and systemic antitumor immunity
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 4 × luc vs 4 × sc189Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunityCancer cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280080_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1176142 and SRA study SRP540217. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 15 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8587143 luc_1 luc
- GSM8587144 luc_2 luc
- GSM8587145 luc_3 luc
- GSM8587146 luc_4 luc
- GSM8587147 sc189_1 sc189
- GSM8587148 sc189_2 sc189
- GSM8587149 sc189_3 sc189
- GSM8587150 sc189_4 sc189
- GSM8587151 RT_IL12_WT_D1
- GSM8587152 RT_IL12_WT_E2
- GSM8587153 RT_IL12_WT_F3
- GSM8587154 RT_J1
- GSM8587155 RT_K2
- GSM8587156 RT_L3
- GSM8587157 RT_M4
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- GSE267158 Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy 48 samples shares immunotherapy, radiotherapy
- GSE311912 Probiotics Complex Synergizes with FOLFOX to Enhance Antitumor Response and Ameliorate Chemotherapy-induced Intestinal Toxicity via Upregulation of NAD+ Metabolism 27 samples shares synergizes, antitumor
- GSE306986 Synergistic Stromal Remodeling and Dual Chemo-Immunotherapy in Pancreatic Cancer: A Two-Stage Losartan-Primed followed Nanocarrier Strategy for Tumor Microenvironment Reprogramming 24 samples shares immunotherapy, program
- GSE235113 Tumor cell intrinsic type I interferon signaling dictates CD47-SIRPα blockade immunotherapy via metabolic reprograming. 22 samples shares immunotherapy, program
- GSE283694 Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalization [RNA-seq] 21 samples shares immunotherapy, immunity
- GSE307570 Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic Homeostasis 20 samples shares radiotherapy, systemic
- GSE279924 Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma 20 samples shares immunotherapy, synergizes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.