Transcriptomic Changes in Adult Hypothalamic Neurons Following Leptin Sensitivity Modulation
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 4 × Neural cells, Palmitic acid, vs 4 × Neural cells, Leptin, vs 4 × Neural cells, leptin antagonist, vs 3 × Neural cells, control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neuronsFrontiers in molecular neuroscience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280030_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1175987 and SRA study SRP540148. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 4 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8585940 Neural cells, control, 3 Neural cells, control,
- GSM8585941 Neural cells, control, 16 Neural cells, control,
- GSM8585942 Neural cells, control, 17 Neural cells, control,
- GSM8585943 Neural cells, Palmitic acid, 19 Neural cells, Palmitic …
- GSM8585944 Neural cells, Palmitic acid, 20 Neural cells, Palmitic …
- GSM8585945 Neural cells, Palmitic acid, 21 Neural cells, Palmitic …
- GSM8585946 Neural cells, Palmitic acid, 40 Neural cells, Palmitic …
- GSM8585947 Neural cells, Leptin, 22 Neural cells, Leptin,
- GSM8585948 Neural cells, Leptin, 23 Neural cells, Leptin,
- GSM8585949 Neural cells, Leptin, 24 Neural cells, Leptin,
- GSM8585950 Neural cells, Leptin, 41 Neural cells, Leptin,
- GSM8585951 Neural cells, leptin antagonist, 25 Neural cells, leptin an…
- GSM8585952 Neural cells, leptin antagonist, 26 Neural cells, leptin an…
- GSM8585953 Neural cells, leptin antagonist, 27 Neural cells, leptin an…
- GSM8585954 Neural cells, leptin antagonist, 42 Neural cells, leptin an…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.