Hepatic transcriptomic changes following equivalent weight loss by calorie restriction or vertical sleeve gastrectomy in mice with hepatic steatosis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosisLiver international : official journal of the International Association for the Study of the Liver · 2023
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE225843_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA937704 and SRA study SRP423979. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7057491 Sham Ad lib 3F
- GSM7057492 Sham Ad lib 4F
- GSM7057493 Sham Ad lib 6F
- GSM7057494 Sham Ad lib 10F
- GSM7057495 Sleeve gastrectomy 1F
- GSM7057496 Sleeve gastrectomy 8F
- GSM7057497 Sleeve gastrectomy 11F
- GSM7057498 Sleeve gastrectomy 18F
- GSM7057499 Sham cal res 2F
- GSM7057500 Sham cal res 9F
- GSM7057501 Sham cal res 15F
- GSM7057502 Sham cal res 16F
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- GSE330380 The effects of adiponectin knockout on hepatic gene expression in male and female C57BL/6NCrl mice fed ad libitum or undergoing caloric restriction 22 samples shares restriction, hepatic
- GSE280030 Transcriptomic Changes in Adult Hypothalamic Neurons Following Leptin Sensitivity Modulation 15 samples shares following, changes
- GSE315829 Investigate changes in gene expression and enriched pathways in endothelial cells following Liver endothelial Heg1 knockout. 13 samples shares following, changes
- GSE309904 Acute kidney injury following fatty liver ischemia-reperfusion injury: indirect protection by hepatic ferroptosis inhibition 12 samples shares following, hepatic
- GSE211550 Macrophages adopt mural cell function and marker expression for vascular support following ischemia 1509 samples shares following
- GSE297702 Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment 219 samples shares following
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.