Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 25 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 20 distinct titles, 5 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiomic analysis of clonal development reveals new regulators of leukemic cell growthGenes & development · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280195_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1177102 and SRA study SRP540494. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 25 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8591387 Aggressive, clone 1, Input
- GSM8591388 Aggressive, clone 1, H3K27ac
- GSM8591389 Aggressive, clone 1, H3K27me3
- GSM8591390 Aggressive, clone 1, H3K4me1
- GSM8591391 Aggressive, clone 1, H3K4me3
- GSM8591392 Aggressive, clone 2, Input
- GSM8591393 Aggressive, clone 2, H3K27ac
- GSM8591394 Aggressive, clone 2, H3K27me3
- GSM8591395 Aggressive, clone 2, H3K4me1
- GSM8591396 Aggressive, clone 2, H3K4me3
- GSM8591397 Early, clone 1, Input
- GSM8591398 Early, clone 1, H3K27ac
- GSM8591399 Early, clone 1, H3K27me3
- GSM8591400 Early, clone 1, H3K4me1
- GSM8591401 Early, clone 1, H3K4me3
- GSM8591402 Early, clone 2, Input
- GSM8591403 Early, clone 2, H3K27ac
- GSM8591404 Early, clone 2, H3K27me3
- GSM8591405 Early, clone 2, H3K4me1
- GSM8591406 Early, clone 2, H3K4me3
- GSM8591407 Normal, Input
- GSM8591408 Normal, H3K27ac
- GSM8591409 Normal, H3K27me3
- GSM8591410 Normal, H3K4me1
- GSM8591411 Normal, H3K4me3
- GSE289108 Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [ChIP-Seq] 57 samples shares remodeling, chip-seq, driven
- GSE272524 Chromatin-dependent motif syntax defines differentiation trajectories [ChIP-seq] 76 samples shares chromatin, chip-seq
- GSE294085 SIRT6 Overexpression Counteracts Chromatin Aging [ChIP-Seq] 74 samples shares chromatin, chip-seq
- GSE295340 Polycomb Chromatin Topology Enables Long-Range Enhancer Recruitment during Craniofacial Development [ChIP-seq] 42 samples shares chromatin, chip-seq
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares chromatin, leukemia
- GSE266022 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [ChIP-seq] 24 samples shares chromatin, chip-seq
- GSE292285 Depletion of lamin-associated polypeptide 2 alpha leads to chromatin reorganization and redistribution of A-type lamins to open genomic regions [ChIP-seq] 22 samples shares chromatin, chip-seq
- GSE314045 Rotational settings quantize nucleosome movement by chromatin regulators 15 samples shares regulators, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.