Actin Dysregulation Induces Neuroendocrine 1 Plasticity and 2 Immune Evasion: A Vulnerability of Small Cell Lung Cancer
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 2 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancerNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280263_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1177476 and SRA study SRP540694. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE286458 MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues [ChIP-seq] 57 samples shares neuroendocrine, induces
- GSE273221 Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice 144 samples shares dysregulation, induces
- GSE284562 Transport stress induces immune dysregulation and exacerbates Mycobacterium tuberculosis infection in mice 28 samples shares dysregulation, induces
- GSE300964 Genetic inactivation of the Translin/Trax RNase activity alters small RNAs including miRNAs, disrupts gene expression and impairs distinct forms of hippocampal synaptic plasticity and memory 18 samples shares plasticity, small
- GSE279200 Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer [Single cell RNA-seq] 14 samples shares neuroendocrine, plasticity
- GSE264598 Prostate adenocarcinoma transition to neuroendocrine small cell tumors requires ASCL1 12 samples shares neuroendocrine, small
- GSE262867 Pancreatic Beta-Cell IL-22 Receptor Deficiency Induces Age-Dependent Dysregulation of Insulin Biosynthesis and Systemic Glucose Homeostasis 10 samples shares dysregulation, induces
- GSE266175 Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities (ChIP-Seq) 84 samples shares plasticity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.