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The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice II

GSE280893 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/11/06 Platform GPL21103
Summary
To compare gene expression between old C57BL6 female mice treated with either control lentivirus or CRISPRa+ lentivirus, we used a flurorescence-based cell sorting to collect neurons expressing GFP (from the sgRNA) from the hippocampus of the mice from each group.Then we performed gene expression analysis using data obtained from RNA-seq of the old neurons in the hippocampus of both groups.
Published in
The maternal X chromosome affects cognition and brain ageing in female mice
Abdulai-Saiku S, Gupta S, Wang D et al. · Nature 2025 · PMID 39843739 · doi:10.1038/s41586-024-08457-y
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Also filed as BioProject PRJNA1180999 and SRA study SRP542659. Searching any of these in the dataset finder brings you back here.

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