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ADSC-Exos can improve acute lung injury by regulating alveolar macrophage polarization through IRF7/NLRP3

GSE280904 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/11/10 Platform GPL24247
Summary
Alveolar macrophages (AMs) are crucial for pulmonary defense and immune regulation. Exosomes from adipose-derived mesenchymal stem cells (ADSC-Exos) have emerged as a promising therapy for inflammatory lung diseases by modulating immune responses. This study investigates the ability of ADSC-Exos to alleviate inflammation in acute lunag injury (ALI), a condition often triggered by sepsis and characterized by lung permeability and respiratory failure.
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Direct links to NCBI, no account and no request form: the whole study as GSE280904_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1181015 and SRA study SRP542670. Searching any of these in the dataset finder brings you back here.

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