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Low-intensity Pulsed Ultrasound regulates osteoclasts mitochondrial function in the treatment of diabetic periodontitis [scRNA-seq]

GSE280908 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/29 Platform GPL28330
Summary
Periodontitis and type Ⅱ diabetes mellitus (T2D) have emerged as prevalent global chronic diseases, with a bidirectional relationship existing between them. Individuals with periodontitis and T2D are susceptible to tooth loss, primarily attributed to alveolar bone resorption resulting from excessive osteoclasts (OC) differentiation. Although low-intensity pulsed ultrasound (LIPUS) is an established treatment method for bone-related conditions, its mechanism of action on OC remains unclear. The aim of this research is to examine the effects and mechanism of on OC within a diabetic inflammatory environment. In summary, our data explored how LIPUS affects OC in the inflammatory environment of diabetes.
Published in
QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF-κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis
Li H, Yang X, Wang H et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 42474035 · doi:10.1002/advs.76650
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Also filed as BioProject PRJNA1181024 and SRA study SRP542686. Searching any of these in the dataset finder brings you back here.

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