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Effect of miRNA26b knockout on vascular calcification [scRNA-seq]

GSE281028 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/11/14 Platform GPL30172
Summary
Vascular calcification is the abnormal deposition of calcium phosphates within the blood vessels. Although it significantly contributes to the development of cardiovascular disease, much remains unknown about the mechanisms driving this process. Recent advances have shown that microRNAs (miRNAs) could be critical in regulating the biological processes driving vascular calcification. Here, we investigated whether miRNA-26b (miR-26b) could regulate vascular calcification. By performing scRNA-seq of the aorta of miR-26b knockout (miR-26bKO) mice, we identified cell-specific targets and demonstrated that components of the BMP signalling pathway are dysregulated in the aortic cell types.
Published in
The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes
Luna Buitrago D, Jover E, Mameli E et al. · Cardiovascular research 2025 · PMID 40737220 · doi:10.1093/cvr/cvaf117
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Also filed as BioProject PRJNA1181857 and SRA study SRP543089. Searching any of these in the dataset finder brings you back here.

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