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Stromal vascular fraction inhibits inhibits kidney fibrosis and inflammation in UUO mice

GSE281130 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/05 Platform GPL34328
Summary
To understand the roles and mechanisms of stromal vascular fraction (SVF) in renal fibrosis induced by unilateral ureteral obstruction (UUO), we performed RNA sequencing of UUO kidneys from PBS- or SVF-treated mice. The transcriptome analysis revealed that SVF triggered significant metabolic reprogramming and improved mitochondrial function. Moreover, SVF treatment inhibited kidney inflammation as revealed by the downregulation of immune cell migration pathway. Furthermore, SVF contributed to the activation of PPAR signaling while inhibited TGF-beta signaling pathway.
Published in
Stromal vascular fraction inhibits renal fibrosis by regulating metabolism and inflammation in obstructive nephropathy
Yue G, Yang Y, Jia H et al. · Frontiers in pharmacology 2025 · PMID 40432888 · doi:10.3389/fphar.2025.1559446
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Also filed as BioProject PRJNA1182357 and SRA study SRP543326. Searching any of these in the dataset finder brings you back here.

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