Corpus callosum bulk RNA sequencing of a cuprizone mouse model of demyelination
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 × Cuprizone BTKi vs 8 × Cuprizone Vehicle vs 4 × Naive Vehicle vs 4 × Naive BTKiGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281180_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182681 and SRA study SRP543675. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8612313 Naive Vehicle 1 Naive Vehicle
- GSM8612314 Naive Vehicle 2 Naive Vehicle
- GSM8612315 Naive Vehicle 3 Naive Vehicle
- GSM8612316 Naive Vehicle 4 Naive Vehicle
- GSM8612317 Naive BTKi 1 Naive BTKi
- GSM8612318 Naive BTKi 2 Naive BTKi
- GSM8612319 Naive BTKi 3 Naive BTKi
- GSM8612320 Naive BTKi 4 Naive BTKi
- GSM8612321 Cuprizone BTKi 1 Cuprizone BTKi
- GSM8612322 Cuprizone BTKi 2 Cuprizone BTKi
- GSM8612323 Cuprizone BTKi 3 Cuprizone BTKi
- GSM8612324 Cuprizone BTKi 4 Cuprizone BTKi
- GSM8612325 Cuprizone BTKi 5 Cuprizone BTKi
- GSM8612326 Cuprizone BTKi 6 Cuprizone BTKi
- GSM8612327 Cuprizone BTKi 7 Cuprizone BTKi
- GSM8612328 Cuprizone BTKi 8 Cuprizone BTKi
- GSM8612329 Cuprizone Vehicle 1 Cuprizone Vehicle
- GSM8612330 Cuprizone Vehicle 2 Cuprizone Vehicle
- GSM8612331 Cuprizone Vehicle 3 Cuprizone Vehicle
- GSM8612332 Cuprizone Vehicle 4 Cuprizone Vehicle
- GSM8612333 Cuprizone Vehicle 5 Cuprizone Vehicle
- GSM8612334 Cuprizone Vehicle 6 Cuprizone Vehicle
- GSM8612335 Cuprizone Vehicle 7 Cuprizone Vehicle
- GSM8612336 Cuprizone Vehicle 8 Cuprizone Vehicle
- GSE255368 Characterization of cuprizone mouse model at single-cell and spatial transcriptomics level[bulk RNA-seq] 13 samples shares cuprizone, bulk
- GSE287320 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model 14 samples shares demyelination, cuprizone
- GSE282130 Tlr7 Drives Sex Differences in Age- and AD-related Demyelination [bulk RNAseq] 69 samples shares demyelination, bulk
- GSE121514 Sequencing of microglia and monocytes during focal remyelination of the corpus callosum 5 samples shares callosum, corpus
- GSE298404 Transcription factor 4 regulates the interhemispheric midline remodeling through neuron–astroglia communications during corpus callosum formation 2 samples shares callosum, corpus
- GSE240815 Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice 16 samples shares demyelination, cuprizone
- GSE243726 OCA-B/Pou2af1 promotes autoimmune demyelination through control of stem-like CD4+ T cells [Bulk RNAseq] 6 samples shares demyelination, bulk
- GSE324634 Effect of L-PGDS loss on cellular response during cuprizone induced demyelination 4 samples shares demyelination, cuprizone
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.