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Effect of L-PGDS loss on cellular response during cuprizone induced demyelination

GSE324634 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/03/20 Platform GPL19057
Summary
L-PGDS is a secretory oligodendrocyte protein; we aimed to determine how the loss of this protein affected the transcriptome of different cell populations during demyelination. We found that very distinct changes in the microglial transcriptome following L-PGDS loss. Specifically, these microglia adopt an aged, dysfunctional gene signature characterized by the increase in ribosomal genes.
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Also filed as BioProject PRJNA1436470 and SRA study SRP683141. Searching any of these in the dataset finder brings you back here.

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