Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × CPZ_Ctrl_OL vs 4 × CPZ_Ctrl_Ast vs 3 × Naive_OL vs 3 × Naive_AstGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSbioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287320_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1212138 and SRA study SRP558092. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8743858 Naive_OL_1 Naive_OL
- GSM8743859 Naive_OL_2 Naive_OL
- GSM8743860 Naive_OL_3 Naive_OL
- GSM8743861 CPZ_Ctrl_OL_1 CPZ_Ctrl_OL
- GSM8743862 CPZ_Ctrl_OL_2 CPZ_Ctrl_OL
- GSM8743863 CPZ_Ctrl_OL_3 CPZ_Ctrl_OL
- GSM8743864 CPZ_Ctrl_OL_4 CPZ_Ctrl_OL
- GSM8743865 Naive_Ast_1 Naive_Ast
- GSM8743866 Naive_Ast_2 Naive_Ast
- GSM8743867 Naive_Ast_3 Naive_Ast
- GSM8743868 CPZ_Ctrl_Ast_1 CPZ_Ctrl_Ast
- GSM8743869 CPZ_Ctrl_Ast_2 CPZ_Ctrl_Ast
- GSM8743870 CPZ_Ctrl_Ast_3 CPZ_Ctrl_Ast
- GSM8743871 CPZ_Ctrl_Ast_4 CPZ_Ctrl_Ast
- GSE287323 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination 19 samples shares oligodendrocytes, demyelination, astrocytes, microglia
- GSE235987 Enhancer-AAVs allow genetic access to diverse populations of astrocytes and oligodendrocytes across species 2040 samples shares oligodendrocytes, astrocytes
- GSE312871 Lesion-remote astrocytes govern microglia-mediated white matter repair II 198 samples shares astrocytes, microglia
- GSE282653 Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination 12 samples shares demyelination, microglia
- GSE302857 Multi-tier signaling and epigenomic reprogramming drive microglial inflammatory states and functions associated with demyelination [RNA-seq] 81 samples shares demyelination, microglia
- GSE271423 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [5xFAD-MITRG Astrocytes 6M] 10 samples shares astrocytes, microglia
- GSE271651 Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [Microglia RNA-seq] 9 samples shares astrocytes, microglia
- GSE316928 Characterizing the metabolomes of microglia, astrocytes, and neurons in the brain across states of health, aging, and disease 35 samples shares astrocytes, microglia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.