Decoupling the Biochemical and Mechanical Effects of Muscle Exercise on Motor Neurons with 2.5D Actuating Matrices [240614Ram_RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × O vs 6 × WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor NeuronsAdvanced healthcare materials · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281241_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182793 and SRA study SRP543622. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8615539 O1 O
- GSM8615540 O2 O
- GSM8615541 O3 O
- GSM8615542 O4 O
- GSM8615543 O5 O
- GSM8615544 O6 O
- GSM8615545 WT1 WT
- GSM8615546 WT2 WT
- GSM8615547 WT3 WT
- GSM8615548 WT4 WT
- GSM8615549 WT5 WT
- GSM8615550 WT6 WT
- GSE281242 Decoupling the Biochemical and Mechanical Effects of Muscle Exercise on Motor Neurons with 2.5D Actuating Matrices 38 samples shares biochemical, decoupling, mechanical, actuating, exercise, matrices, neurons
- GSE289885 Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing 29 samples shares biochemical, mechanical
- GSE253816 Morphine-responsive neurons that regulate mechanical antinociception 21 samples shares mechanical, neurons
- GSE249554 The neuroprotective effect of TGF-β1 on mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis 12 samples shares mechanical, neurons
- GSE281942 Bioenergetic programs of cancellous and cortical bone are distinct and differ with age and mechanical loading 150 samples shares mechanical
- GSE283659 Skeletal dysplasia-causing mutations in TRPV4 alter the chondrocyte’s transcriptomic response to mechanical loading 71 samples shares mechanical
- GSE271916 Comparative transcriptomic studies to determine the molecular effects of titin mechanical knock-out in skeletal muscles 56 samples shares mechanical
- GSE269698 Mechanical regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle 48 samples shares mechanical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.