Decoupling the Biochemical and Mechanical Effects of Muscle Exercise on Motor Neurons with 2.5D Actuating Matrices
RNA-seq (gene expression) · mouse · 38 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 38 samples: 7 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor NeuronsAdvanced healthcare materials · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281242_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182790 and SRA study SRP543622. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 38 samples.
How we read this: 7 replicated groups read from 38 sample titles; they account for 38 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8107900 M1 M
- GSM8107901 M2 M
- GSM8107902 M3 M
- GSM8107903 M4 M
- GSM8107904 MC1 MC
- GSM8107905 MC2 MC
- GSM8107906 MC3 MC
- GSM8107907 MC4 MC
- GSM8107908 LI1 LI
- GSM8107909 LI2 LI
- GSM8107910 LI3 LI
- GSM8107911 LI4 LI
- GSM8107912 LI5 LI
- GSM8107913 LI6 LI
- GSM8107914 C1 C
- GSM8107915 C2 C
- GSM8107916 C3 C
- GSM8107917 C4 C
- GSM8107918 C5 C
- GSM8107919 C6 C
- GSM8107920 HI1 HI
- GSM8107921 HI2 HI
- GSM8107922 HI3 HI
- GSM8107923 HI4 HI
- GSM8107924 HI5 HI
- GSM8107925 HI6 HI
- GSM8615539 O1 O
- GSM8615540 O2 O
- GSM8615541 O3 O
- GSM8615542 O4 O
- GSM8615543 O5 O
- GSM8615544 O6 O
- GSM8615545 WT1 WT
- GSM8615546 WT2 WT
- GSM8615547 WT3 WT
- GSM8615548 WT4 WT
- GSM8615549 WT5 WT
- GSM8615550 WT6 WT
- GSE281241 Decoupling the Biochemical and Mechanical Effects of Muscle Exercise on Motor Neurons with 2.5D Actuating Matrices [240614Ram_RNA-seq] 12 samples shares biochemical, decoupling, mechanical, actuating, exercise, matrices, neurons, muscle
- GSE271916 Comparative transcriptomic studies to determine the molecular effects of titin mechanical knock-out in skeletal muscles 56 samples shares mechanical, muscle
- GSE269698 Mechanical regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle 48 samples shares mechanical, muscle
- GSE289885 Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing 29 samples shares biochemical, mechanical
- GSE253816 Morphine-responsive neurons that regulate mechanical antinociception 21 samples shares mechanical, neurons
- GSE265982 Skeletal muscle specific overexpression of miRNA-1 impairs mechanical overload-induced skeletal muscle hypertrophy [RNA-Seq] 20 samples shares mechanical, muscle
- GSE249554 The neuroprotective effect of TGF-β1 on mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis 12 samples shares mechanical, neurons
- GSE263619 Hydrogel biomaterials that stiffen and soften on demand reveal that skeletal muscle stem cells harbor a mechanical memory 10 samples shares mechanical, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.