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The host-adapted commensal fungus provides cross-kingdom protection

GSE281418 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/24 Platform GPL21103
Summary
Fungi are ubiquitous in the environment and, like bacteria, are an integral part of the gut microbiome. However, unlike bacteria, fungal species that can stably colonize the murine gut and model commensal behavior remain elusive. Here, we show that Kazachstania pintolopesii, a dominant fungus found in pet store mice from geographically distinct regions, stably colonized laboratory mice. K. pintolopesii outcompeted other fungi and maintained stable colonization independent of gut bacteria. We find that K. pintolopesii does not induce a typical antifungal response in murine hosts locally in the gut or upon systemic challenge. Accordingly, K. pintolopesii colonization did not afford protection against systemic fungal infection by Candida albicans. Instead, K.pintolopessii colonization increased type 2 immune responses in the intestine and protected mice against helminth infection.
Published in
A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection
Han G, Yunker R, Hasan MH et al. · bioRxiv : the preprint server for biology 2026 · PMID 41542591 · doi:10.1101/2025.04.30.651489
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Also filed as BioProject PRJNA1183828 and SRA study SRP544019. Searching any of these in the dataset finder brings you back here.

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