Inherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility [atrial tissue]
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 6 × Atrial tissue WT vs 4 × Atrial tissue HetGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibilityAmerican journal of physiology. Heart and circulatory physiology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281559_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1184722 and SRA study SRP544451. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8623411 Atrial tissue WT1 Atrial tissue WT
- GSM8623412 Atrial tissue WT2 Atrial tissue WT
- GSM8623413 Atrial tissue WT3 Atrial tissue WT
- GSM8623414 Atrial tissue WT4 Atrial tissue WT
- GSM8623415 Atrial tissue WT5 Atrial tissue WT
- GSM8623416 Atrial tissue WT6 Atrial tissue WT
- GSM8623417 Atrial tissue Het1 Atrial tissue Het
- GSM8623418 Atrial tissue Het2 Atrial tissue Het
- GSM8623419 Atrial tissue Het3 Atrial tissue Het
- GSM8623420 Atrial tissue Het4 Atrial tissue Het
- GSE334551 NAD+ Deficiency Drives Metabolic Dysfunction-Associated Atrial Fibrillation 29 samples shares fibrillation, dysfunction
- GSE319401 Exercise Mitigates Cardiac Dysfunction Post-MI in Ovariectomized Mice via miR-21/Sox7-Mediated Suppression of Cardiac Fibroblast Activation 24 samples shares dysfunction, fibroblast
- GSE280782 Preterm birth increases susceptibility to hyperglycemia-induced glomerular alterations in the kidneys of male mice 24 samples shares susceptibility, increases
- GSE289751 Resolution of inflammation in imprinted fibroblast-like synoviocytes establishes a transcriptomic signature that promotes endothelial cell dysfunction. 12 samples shares dysfunction, fibroblast
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares dysfunction, fibroblast
- GSE312968 Reversible Fibroblast Trajectories Regulated by MR Underlie Diastolic Dysfunction 12 samples shares dysfunction, fibroblast
- GSE309251 Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction 347 samples shares dysfunction
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares susceptibility
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.