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Tuberous Sclerosis Complex Regulates Progenitor Balance and Upper Layer Neuronal Generation During the Development and Evolution of the Cerebral Cortex

GSE281619 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/09/22 Platform GPL19057
Summary
Radial progenitors serve to coordinate the generation and placement of appropriate numbers and types of neurons in the developing cerebral cortex. Radial progenitors divide asymmetrically to generate neurogenic intermediate progenitors (IPs) and the symmetric proliferation of IPs rapidly expands cortical neuronal population. The temporal maintenance of a balanced diversity of cortical progenitors and the resultant generation, placement, and connectivity of appropriate numbers of different classes of neurons serve as a blueprint to guide the formation of a properly wired cerebral cortex. Here, we show that Tuberous Sclerosis Complex proteins function to facilitate radial progenitor/intermediate progenitor balance and the generation of upper-layer neurons. Regulation of TSC expression levels during human brain evolution may lead to the expanded generation of upper-layer neurons necessary for higher-order brain functions in humans.
Published in
TSC tunes progenitor balance and upper-layer neuron generation in neocortex
Casingal CR, Nakagawa N, Yabuno-Nakagawa K et al. · Nature 2026 · PMID 41339559 · doi:10.1038/s41586-025-09810-5
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Also filed as BioProject PRJNA1184807 and SRA study SRP544698. Searching any of these in the dataset finder brings you back here.

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