Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltration
RNA-seq (gene expression) · mouse · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Local radiation enhances systemic CAR T-cell efficacy by augmenting antigen crosspresentation and T-cell infiltrationBlood advances · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281695_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1185241 and SRA study SRP544728. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 3 as controls.
How we read this: 9 replicated groups read from 25 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8626296 Control 201 Control
- GSM8626297 Control 202 Control
- GSM8626298 Control 203 Control
- GSM8626299 1x8 24h IR 211 1x8 24h I
- GSM8626300 1x8 24h IR 212 1x8 24h I
- GSM8626301 1x8 24h IR 213 1x8 24h I
- GSM8626302 1x8 24h NIR 211 1x8 24h NI
- GSM8626303 1x8 24h NIR 212 1x8 24h NI
- GSM8626304 1x8 24h NIR 213 1x8 24h NI
- GSM8626305 1x8 7d IR 214 1x8 7d I
- GSM8626306 1x8 7d IR 215 1x8 7d I
- GSM8626307 1x8 7d NIR 214 1x8 7d NI
- GSM8626308 1x8 7d NIR 215 1x8 7d NI
- GSM8626309 2x4 24h IR 206 2x4 24h I
- GSM8626310 2x4 24h IR 207 2x4 24h I
- GSM8626311 2x4 24h IR 208 2x4 24h I
- GSM8626312 2x4 24h NIR 206 2x4 24h NI
- GSM8626313 2x4 24h NIR 207 2x4 24h NI
- GSM8626314 2x4 24h NIR 208 2x4 24h NI
- GSM8626315 2x4 7d IR 209 2x4 7d I
- GSM8626316 2x4 7d IR 210 2x4 7d I
- GSM8626317 2x4 7d NIR 209 2x4 7d NI
- GSM8626318 2x4 7d NIR 210 2x4 7d NI
- GSM8626319 Tumor draining Lymh Nodes 1x8Gy 24h
- GSM8626320 Tumor draining Lymh Nodes 2x4Gy 24h
- GSE227189 Single cell transcriptomic analyses of the dynamic local and systemic response to cardiac injury in mice and zebrafish [mouse] 28 samples shares car, systemic
- GSE279393 CAR T Cells Secreting NGF-Neutralizing scFv Enhance Efficacy in Clear Cell Renal Cell Carcinoma by Relieving Immunosuppression through Immunosympathectomy [bulk RNA-seq] 17 samples shares car, efficacy
- GSE269680 CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma (spatial) 15 samples shares car, efficacy
- GSE261367 FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease 11 samples shares car, radiation
- GSE327494 Localized PD-1 CAR T therapy reprograms neuroinflammation - mouse CAR T data. 302 samples shares car
- GSE201417 Gene expression profiles of cardiac neural crest cells during heart development 294 samples shares car
- GSE241587 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin cardiomyopathy mice [sci-RNA-seq] 96 samples shares car
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares car
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.