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mRNA profiles of Celf1fl/fl and adipocyte-specific Celf1 deficiency (Celf1fl/fl AKO) in iWAT after acute cold stimulation

GSE281771 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/05 Platform GPL28457
Summary
RNA-seq reveals the critical role of adipocyte Celf1 in cold-responsive thermogenic remodeling in inguinal white adipose tissue (iWAT). The cold-induced thermogenic program in iWAT was severely blunted in Celf1AKO mice, especially the obvious downregulation of Ucp1, Dio2, Elvol3, Tbx1, Cox7a1, and Cidea genes. The GO analysis revealed that the down-regulated genes were primarily involved in adaptive thermogenesis, temperature homeostasis, and mitochondrial-related processes, including lipid oxidation, fatty acid metabolism and so on. KEGG pathway analysis further showed that these down-regulated genes were involved in thermogenesis-related pathways, including thermogenesis, PPAR signaling, metabolic pathways, fatty acid degradation, and AMPK signaling. Together, these results suggest that adipocyte Celf1 deficiency impairs cold-induced iWAT thermogenic program.
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Also filed as BioProject PRJNA1181284 and SRA study SRP542784. Searching any of these in the dataset finder brings you back here.

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