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MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids

GSE281781 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 186 samples Submitted 2026/02/06 Platform GPL30172Platform GPL30173
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 186 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
186 samples: 58 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybridsCell · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids
Uhl L, Aziba A, Löbbert S et al. · Cell 2026 · PMID 41576951 · doi:10.1016/j.cell.2025.12.019
This dataset
Open GSE281781 in finder → Find more ChIP / ATAC / CUT&Tag datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281781_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1185699 and SRA study SRP544524. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41576951) ↗
Study design
58 conditions, mostly in duplicate
mRNA_KPC_MYC_MUT_III ×3 mRNA_KPC_MYC_WT ×3 mRNA_KPC_shMYC ×3 ChIP_Rx_U2OSMYCtetOn_Input_DMSO ×2 ChIP_Rx_U2OSMYCtetOn_Input_CBL0137 ×2 ChIP_Rx_U2OSMYCtetOn_Input_PlaB ×2 ChIP_Rx_U2OSMYCtetOn_MYC_IP_DMSO ×2 ChIP_Rx_U2OSMYCtetOn_MYC_IP_CBL0137 ×2 +117 more

Supports a between-group comparison across 119 samples.

How we read this: 58 replicated groups read from 186 sample titles; they account for 119 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 146 more — browse all 186 samples with per-sample file links →

Datasets on a similar topic

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