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The effect of Dinc defficiency on the mouse paneth cell transcriptome

GSE281801 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/26 Platform GPL19057
Summary
We invstigated the effect of zinc depletion on the mouse intestine, and specifically on paneth cells. Mice ere placed on a zinc depleted diet for 7 weeks after which the the effects of dietary zinc shortage on paneth cells were investigated. A zinc is an essential element for correct paneth cell function and zinc defficiency is a human and animal health problem investigating the PC transcriptom my provide valuable insights into the exact mechanism.
Published in
Detection of chimeric alpha-defensin transcripts and peptides in mouse Paneth cells
Timmermans S, Wallaeys C, De Beul S et al. · Frontiers in immunology 2025 · PMID 39981239 · doi:10.3389/fimmu.2025.1543059
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Also filed as BioProject PRJNA1185733 and SRA study SRP545092. Searching any of these in the dataset finder brings you back here.

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