FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 25 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Prostate cancerThis series is part of our curated briefing on it.
- Samples
- 25 samples: 21 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironmentNature communications · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282726_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1190070 and SRA study SRP656839. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 25 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8649315 ADPC/NEPC Patient 1
- GSM8649343 P12 [Visium]
- GSM8649344 PF12 [Visium]
- GSM8649345 P18 [Visium]
- GSM8649346 PF18 [Visium]
- GSM8649347 P12
- GSM8649348 PF12
- GSM8649349 P18
- GSM8649350 PF18
- GSM8649351 XP
- GSM8649352 XPF
- GSM8649353 P15
- GSM8649354 PF15
- GSM9377752 Mice-1751, prostate tissue, Pten/Foxa1 Double Knock Out, FOXA1(ChIP)
- GSM9377753 Mice-1751, prostate tissue, Pten/Foxa1 Double Knock Out, H3K27ac(ChIP)
- GSM9377754 Mice-2378, prostate tissue, Pten/Foxa1 Double Knock Out, ,FOXA1(ChIP)
- GSM9377755 Mice-2378, prostate tissue, Pten/Foxa1 Double Knock Out, H3K27ac(ChIP)
- GSM9377756 Mice-2033, prostate tissue, Pten Single Knock Out, ,FOXA1(ChIP)
- GSM9377757 Mice-2033, prostate tissue, Pten Single Knock Out, H3K27ac(ChIP)
- GSM9377758 Mice-2717, prostate tissue, Pten Single Knock Out, ,FOXA1(ChIP)
- GSM9377759 Mice-2717, prostate tissue Pten Single Knock Out, H3K27ac(ChIP)
- GSM9377760 Mice-2573, prostate tissue, Pten Single Knock Out, ,FOXA1(ChIP)
- GSM9377761 Mice-2573, prostate tissue, Pten Single Knock Out, H3K27ac(ChIP)
- GSM9377762 Mice-1943, prostate tissue, Pten/Foxa1 Double Knock Out, ,FOXA1(ChIP)
- GSM9377763 Mice-1943, prostate tissue, Pten/Foxa1 Double Knock Out, H3K27ac(ChIP)
- GSE115501 RNA sequencing on circulating tumor cells from prostate cancer patients 136 samples same disease briefing · shares prostate
- GSE222467 The RNA binding proteins LARP4A and LARP4B promote tumour growth and metastasis in prostate cancer and osteosarcoma 12 samples same disease briefing · shares prostate
- GSE300947 A novel six-biomarker panel identified from male breast cancer-associated fibroblasts demonstrates prognostic power for prostate tumors 6 samples same disease briefing · shares prostate
- GSE120181 Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment 2 samples same disease briefing · shares prostate
- GSE71008 Plasma extracellular RNA profiles in healthy and cancer patients 192 samples same disease briefing
- GSE242541 ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity 12 samples same disease briefing
- GSE260725 Individual RNA-seq for different prostate cancer cells and Lucap35CR PDX treated by SR8278,JQ1,AZD5153,ENZ or by FOXA1 and NR1D1 gene knockdown or NR1D1 overexpression. 26 samples shares foxa1, prostate
- GSE152277 G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT 30 samples shares immunosuppressive, microenvironment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.