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Comparison of CRISPR-Cas9 genome-edited JEG-3 TAZ/WWTR1 knockout and wild type choriocarcinoma cells

GSE282831 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/28 Platform GPL18573
Summary
The transcriptional co-activator TAZ/WWTR1 plays a central role in the Hippo signaling pathway and acts as crucial mediator in maintaining organ size and tissue homeostasis. Changes in its activity can lead to diseases, including cancer, due to uncontrolled cell growth or aberrant cellular behavior. The aim of this study was to identify gene signatures that are specifically regulated by TAZ in human trophoblast cells. This was achieved by comparing JEG-3 wild-type and TAZ knockout choriocarcinoma cells, generated with CRISPR-Cas9 technology.
Published in
The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta
Meinhardt G, Waldhäusl H, Lackner AI et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 40228123 · doi:10.1073/pnas.2426385122
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Also filed as BioProject PRJNA1190490 and SRA study SRP547543. Searching any of these in the dataset finder brings you back here.

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