Single-nucleus RNA sequencing of the kidney from an early-stage chronic calcineurin inhibitor nephrotoxicity mouse model
Single-nucleus RNA-seq · mouse · 2 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Pyruvate Dehydrogenase and Cellular Metabolism in Calcineurin Inhibitor-Induced Kidney FibrosisJournal of the American Society of Nephrology : JASN · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283130_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1192215 and SRA study SRP548343. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE293503 Single-nucleus RNA Sequencing of Kidney and Brain Samples from Young WT and Klotho KO Male Mice 4 samples shares single-nucleus, kidney
- GSE254360 Single-nucleus transcriptomic analysis of the amygdala of mice in acute and chronic neuropathic pain 15 samples shares single-nucleus, chronic
- GSE263648 Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress 8 samples shares single-nucleus, chronic
- GSE329633 Single-nucleus profiling reveals that cardiomyocyte loss and inflammation drive microenvironment remodeling in early-stage PKP2-deficient ARVC 4 samples shares single-nucleus, early-stage
- GSE255545 Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets and promotes chronic GVHD 3 samples shares calcineurin, chronic
- GSE331205 Single-nucleus multiome RNA and ATAC sequencing of mouse kidney in kidney-specific Glut2 knockout (rGlut2 KO) 4 samples shares single-nucleus, kidney
- GSE84371 Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons 924 samples shares single-nucleus
- GSE246154 Single-nucleus RNA-sequencing (snRNA-Seq) of brain cells from tumor-bearing C57BL/6 mice 19 samples shares single-nucleus
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.