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Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress

GSE263648 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/13 Platform GPL24247
Summary
It is widely believed that stress and heart disease are related, but the exact mechanisms remain debatable. The Chronic Unpredictable Mild Stress (CUMS) paradigm can generally be regarded as an effective animal stress model, as it better simulates the stress frequently experienced by humans and prevents animals from adapting to a specific type of stress. To systematically understand the transcriptomic changes in cardiovascular stress-induced injury and lay the foundation for subsequent research on diagnostic and therapeutic targets, we further characterized the mRNA expression profiles of all cardiomyocytes in the left ventricle of mouse hearts using single-nucleus transcriptomics on the 10x Genomics platform.
Published in
Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress
Li Y, Liu X, Zhang H et al. · Scientific data 2025 · PMID 40651984 · doi:10.1038/s41597-025-05556-x
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Also filed as BioProject PRJNA1097003 and SRA study SRP500483. Searching any of these in the dataset finder brings you back here.

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