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Single-nucleus RNA Sequencing of Kidney and Brain Samples from Young WT and Klotho KO Male Mice

GSE293503 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/23 Platform GPL28457
Summary
This dataset includes single-nucleus gene expression profiles from kidney and cerebral cortex samples of a young male C57BL/6J mouse with α-klotho gene knockout, along with the age-matched wild-type control. This short-lived model was used to validate transcriptomic clocks and to comprehensively characterize the molecular hallmarks of mortality associated with this genetic modification.
Published in
Universal transcriptomic hallmarks of mammalian ageing and mortality
Tyshkovskiy A, Kholdina D, Davitadze M et al. · Nature 2026 · PMID 42203874 · doi:10.1038/s41586-026-10542-3
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Direct links to NCBI, no account and no request form: the whole study as GSE293503_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1244833 and SRA study SRP575777. Searching any of these in the dataset finder brings you back here.

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