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The impact of CXCL13 and IL-9 expression on CAR T cell functionality

GSE283222 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/11 Platform GPL24247
Summary
CXCL13 expression is highly elevated in T cells from patients who respond to PD-1 blockade, suggesting that CXCL13 may play a role in boosting T cell antitumor responses. Compared to conventional Th1/Tc1 cells, Th9/Tc9 cells exhibit stronger antitumor functions, and IL-9 plays a critical role in mediating their antitumor efficacy. Therefore, we investigate the respective effects of CXCL13 and IL-9 on CAR T cells.
Published in
CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD-1 Blockade
Zhou Y, Zhao W, Zhu Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40492496 · doi:10.1002/advs.202508095
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Also filed as BioProject PRJNA1192532 and SRA study SRP548515. Searching any of these in the dataset finder brings you back here.

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