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The effects of sorafenib treatment on the Hep1-6 tumor tissue

GSE283371 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/05 Platform GPL24247
Summary
This study aimed to investigate the transcriptomic changes in subcutaneous Hepa1-6 tumor tissues of mice following intraperitoneal administration of sorafenib, a tyrosine kinase inhibitor, versus a control solvent. Mice were injected with either sorafenib or the control solvent four times, according to the experimental design. After the treatment period, tumor samples were collected and subjected to RNA sequencing (RNA-seq) to analyze the gene expression profiles. The results from this RNA-seq analysis provide insights into the molecular mechanisms underlying the response of Hepa1-6 tumors to sorafenib treatment, potentially identifying novel therapeutic targets and biomarkers for hepatocellular carcinoma.
Published in
Sorafenib Promotes Treg Cell Differentiation To Compromise Its Efficacy via VEGFR/AKT/Foxo1 Signaling in Hepatocellular Carcinoma
Shen Y, Wang H, Ma Z et al. · Cellular and molecular gastroenterology and hepatology 2025 · PMID 39743020 · doi:10.1016/j.jcmgh.2024.101454
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Direct links to NCBI, no account and no request form: the whole study as GSE283371_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1193538 and SRA study SRP549028. Searching any of these in the dataset finder brings you back here.

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