C/EBP⍺ activates Irf8 expression in myeloid progenitors at the +56 kb
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 developmentScience immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283421_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1193611 and SRA study SRP549101. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8662348 WT_1, H3K27ac CUT&RUN
- GSM8662349 WT_2, H3K27ac CUT&RUN
- GSM8662350 d1pm_1, H3K27ac CUT&RUN
- GSM8662351 d1pm_2, H3K27ac CUT&RUN
- GSM8662352 d1_1, H3K27ac CUT&RUN
- GSM8662353 d1_2, H3K27ac CUT&RUN
- GSM8662354 d12_1, H3K27ac CUT&RUN
- GSM8662355 d12_2, H3K27ac CUT&RUN
- GSM8662356 IRF8KO, H3K27ac CUT&RUN
- GSM8662357 T, H3K27ac CUT&RUN
- GSE304958 Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency 40 samples shares ebp, activates
- GSE326003 The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence [RNA-seq] 165 samples shares progenitors, myeloid
- GSE266188 Profiling of gene expression, histone marks, chromatin accessibility, and DNA methylation in myeloid progenitors expressing H3WT, H3K4M, H3K27M, or H3K4M/K27M for 2 weeks [CUT&Tag] 36 samples shares progenitors, myeloid
- GSE289311 Erythropoietin Exposure Impairs B Cell Development and Promotes Myeloid-Imprinted Biphenotypic Progenitors 96 samples shares progenitors, myeloid
- GSE281377 Microbiota exposure following DSS-induced colitis promotes Mincle-mediated training of myeloid progenitors 54 samples shares progenitors, myeloid
- GSE264083 Mycobacterium abscessus infection in fetal liver derived alveolar-like macrophages activates distinct inflammatory responses compared to myeloid-derived macrophages 36 samples shares activates, myeloid
- GSE281440 Pre-occupied ATF4 relies on CEBPγ co-binding for robust transcription activation during integrated stress response [CUT&Tag] 20 samples shares ebp
- GSE280981 ChREBP-mediated control of Them1 expression coordinates thermogenesis with glycolysis and lipogenesis 26 samples shares ebp
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.