Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [802T4]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 ComplexesCancer discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303263_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1294621 and SRA study SRP602640. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 5 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9122084 _802T4_IgG_rep1 802T4_IgG
- GSM9122085 _802T4_CTCF
- GSM9122086 _802T4_H3K4me3_rep1 802T4_H3K4me3
- GSM9122087 _802T4_H3K4me3_rep2 802T4_H3K4me3
- GSM9122088 _802T4_H3K14ac_rep1 802T4_H3K14ac
- GSM9122089 _802T4_H3K14ac_rep2 802T4_H3K14ac
- GSM9122090 _802T4_KAT7_rep1 802T4_KAT7
- GSM9122091 _802T4_KAT7_rep2 802T4_KAT7
- GSM9122092 _802T4_IgG_rep2 802T4_IgG
- GSM9122093 _802T4_H3K4me3_rep3 802T4_H3K4me3
- GSM9122094 _802T4_KMT2A_rep1 802T4_KMT2A
- GSM9122095 _802T4_KMT2A_rep2 802T4_KMT2A
- GSE281967 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [bullk ATAC-seq] 21 samples shares hbo1, mll1, coordinated, suppression, epigenomic, regulators, complexes
- GSE303178 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KPTC CUT&RUN] 12 samples shares hbo1, mll1, coordinated, suppression, epigenomic, regulators, complexes
- GSE303264 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KP787] 11 samples shares hbo1, mll1, coordinated, suppression, epigenomic, regulators, complexes
- GSE282851 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [scRNA-seq] 10 samples shares hbo1, mll1, coordinated, suppression, epigenomic, regulators, complexes
- GSE283530 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [ChIP-Seq] 16 samples shares hbo1, complexes
- GSE249215 Non-Canonical PRC1.1 is required for the activity of Menin-MLL1 Inhibitors in NUP98-Rearranged AML [ChIP-Seq] 171 samples shares mll1
- GSE311724 Effects of loss of KAT6A on histone acetylation and methylation levels, as well as MLL1 and POLR2A occupancy 134 samples shares mll1
- GSE248781 The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells [ChIP-seq] 8 samples shares mll1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.