GEO series

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

GSE28359 Homo sapiens Expression profiling by array 8 samples Submitted 2011/04/04 Platform GPL570

Summary

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy. LGC006, a less potent SR1 analog, was also examined. KEYWORDS: two compounds, multiple doses, one time point

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Direct links to NCBI, no account and no request form: the whole study as GSE28359_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples.

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Also filed as BioProject PRJNA139419. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 20688981) ↗

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