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cMaf supports Zeb2 expression for primitive hematopoiesis (Multiome)

GSE283596 Mus musculus Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/26 Platform GPL34290
Summary
Tissue-resident macrophages (TRMs) are essential for tissue homeostasis and play a key role in disease and pathology. They originate from distinct waves of hematopoietic progenitors, including primitive, transient-definitive, and definitive hematopoiesis. We found that loss of the Zeb2 ‒165kb enhancer impairs monocyte development and alters TRM transcriptional landscapes, with only HSC-derived monocytes requiring Zeb2 for their development. In Zeb2∆‒165kb mice, primitive TRMs persist in tissues due to the lack of replacement by later hematopoietic waves, and Maf is required for maintaining Zeb2 expression in primitive macrophages.
Published in
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
Chen J, Du S, Cheng W et al. · Immunity 2026 · PMID 41455473 · doi:10.1016/j.immuni.2025.11.022
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Also filed as BioProject PRJNA1194598 and SRA study SRP549632. Searching any of these in the dataset finder brings you back here.

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