GEO series
An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS [multiome]
GSE306675
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
10 samples
2025/08/27
GPL21626
Summary
To uncover molecular determinants of motor neuron degeneration and selective vulnerability in amyotrophic lateral sclerosis (ALS), we performed longitudinal single-nucleus RNA sequencing, paired single-nucleus RNA and ATAC sequencing, and MERFISH spatial transcriptomics from control and SOD1-G93A mouse spinal cords. For the final snRNA-seq analysis, control experiments from Blum et al., Nat Neurosci, 2021 (GEO accession: GSE161621) were also used.
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