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Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity

GSE283770 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/01 Platform GPL24247
Summary
Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset. Eepd1 is primarily expressed in adipose tissue, where its downregulation or deletion accelerates obesity development. We show that Eepd1 ablation in vivo hinders PKA activation, thereby inhibiting lipolysis and thermogenesis in adipose tissue. leading to obesity progression and dysregulation of glucose metabolism. This study reveals Eepd1’s unexpected role in promoting adipose lipolysis and thermogenesis, underscoring its potential as a promising therapeutic target to combat obesity.
Published in
Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity
Chen S, Wang Y, Zhou Q et al. · Nature communications 2025 · PMID 39809799 · doi:10.1038/s41467-025-56026-2
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Also filed as BioProject PRJNA1195567 and SRA study SRP550063. Searching any of these in the dataset finder brings you back here.

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