← BioTransfer GEO Dataset Finder
GEO series

Differential chromatin accessibilty at MAPK- and Wnt-dependent transcription factor motifs in metastatic CRC tumors

GSE284055 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/01/08 Platform GPL17021
Summary
Colorectal cancer, a leading cause of cancer-related mortality due to distant metastases, is driven by activating mutations in the Wnt and MAPK pathways. Understanding the interplay between these crucial pathways during metastatic progression is essential for developing effective treatments. Here we developed an immunocompetent mouse model of metastatic colorectal cancer using in vivo orthotopic passaging. We demonstrate that highly metastatic tumor cells show increased accessibility of AP-1 TF motifs and less accessibility at TCF/LEF, suggesting higher MAPK and less WNT activity, respectively.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE284055_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1196914 and SRA study SRP550816. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.