GEO series
TEX cell fate and differentiation are shaped by 3D genome reorganization and chromatin architecture integrity [D3]
GSE284090
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
18 samples
2026/06/03
GPL21273
Summary
CTCF is recognized for its role in facilitating long-range chromatin interactions and 3D genome organization. In CD8+ T cells responding to chronic infection, CTCF undergoes redistribution to activate the exhausted cytotoxic effector (Tex-eff) program while simultaneously utilizing its insulation function to regulate the fate of precursors to stem-like exhausted T (Tex-prec) cells.
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