Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in Mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in MiceAging cell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284125_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1197399 and SRA study SRP551071. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8678180 RPE cells, 5-month-old mouse 1_left eye
- GSM8678181 RPE cells, 5-month-old mouse 1_right eye
- GSM8678182 RPE cells, 5-month-old mouse 2_left eye
- GSM8678183 RPE cells, 5-month-old mouse 2_right eye
- GSM8678184 RPE cells, 5-month-old mouse 3_left eye
- GSM8678185 RPE cells ,5-month-old mouse 3_right eye
- GSM8678186 RPE cells, 22-month-old mouse 1_left eye
- GSM8678187 RPE cells, 22-month-old mouse 1_right eye
- GSM8678188 RPE cells, 22-month-old mouse 2_left eye
- GSM8678189 RPE cells, 22-month-old mouse 2_right eye
- GSM8678190 RPE cells, 22-month-old mouse 3_left eye
- GSM8678191 RPE cells ,22-month-old mouse 3_right eye
- GSE281823 Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy 40 samples shares degeneration, autophagy
- GSE325919 Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans 30 samples shares age-associated, decline
- GSE307834 Intestinal interoceptive dysfunction drives age-associated cognitive decline [RNA-Seq] 20 samples shares age-associated, decline
- GSE173999 Single-cel RNA-seq of Mouse Olfactory Epithelium for Understanding Age-associated Neuronal Injury Response 19 samples shares age-associated, epithelium
- GSE272674 An in vitro high-content screening unveils miR-429 as a protective molecule in photoreceptor degeneration models 18 samples shares degeneration, protective
- GSE230723 The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments 12 samples shares age-associated, decline
- GSE314043 Inhibition of P2RX7 Protects Against Light-Induced Retinal Degeneration by Suppressing cGAS-STING Signaling II 10 samples shares light-induced, degeneration
- GSE317412 Dietary Glutamine Supplementation Mitigates Age-Associated Cardiac Decline by Restricting H3K27me3 14 samples shares age-associated, decline
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.