Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans
RNA-seq (gene expression) · mouse · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 30 samples: 30 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humansProceedings of the National Academy of Sciences of the United States of America · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE325919_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1442422 and SRA study SRP686459. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 30 sample titles: 30 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9617239 S_1 (Wild type, non-trained, female, muscle sample)
- GSM9617240 S_2 (Wild type, non-trained, female, muscle sample)
- GSM9617241 S_3 (Wild type, non-trained, female, muscle sample)
- GSM9617242 S_4 (Wild type, non-trained, female, muscle sample)
- GSM9617243 S_5 (Wild type, non-trained, female, muscle sample)
- GSM9617244 S_6 (Wild type, trained, female, muscle sample)
- GSM9617245 S_7 (Wild type, trained, female, muscle sample)
- GSM9617246 S_8 (Wild type, trained, female, muscle sample)
- GSM9617247 S_9 (Wild type, trained, female, muscle sample)
- GSM9617248 S_10 (Wild type, trained, female, muscle sample)
- GSM9617249 S_11 (G6PD-tg, non-trained, female, muscle sample)
- GSM9617250 S_12 (G6PD-tg, non-trained, female, muscle sample)
- GSM9617251 S_13 (G6PD-tg, non-trained, female, muscle sample)
- GSM9617252 S_14 (G6PD-tg, non-trained, female, muscle sample)
- GSM9617253 S_15 (G6PD-tg, non-trained, female, muscle sample)
- GSM9617259 S_21 (Wild type, non-trained, male, muscle sample)
- GSM9617260 S_22 (Wild type, non-trained, male, muscle sample)
- GSM9617261 S_23 (Wild type, non-trained, male, muscle sample)
- GSM9617262 S_24 (Wild type, non-trained, male, muscle sample)
- GSM9617263 S_25 (Wild type, non-trained, male, muscle sample)
- GSM9617264 S_26 (Wild type, trained, male, muscle sample)
- GSM9617265 S_27 (Wild type, trained, male, muscle sample)
- GSM9617266 S_28 (Wild type, trained, male, muscle sample)
- GSM9617267 S_29 (Wild type, trained, male, muscle sample)
- GSM9617268 S_30 (Wild type, trained, male, muscle sample)
- GSM9617269 S_31 (G6PD-tg, non-trained, male, muscle sample)
- GSM9617270 S_32 (G6PD-tg, non-trained, male, muscle sample)
- GSM9617271 S_33 (G6PD-tg, non-trained, male, muscle sample)
- GSM9617272 S_34 (G6PD-tg, non-trained, male, muscle sample)
- GSM9617273 S_35 (G6PD-tg, non-trained, male, muscle sample)
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, decline
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares mitochondrial, skeletal
- GSE284125 Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in Mice 12 samples shares age-associated, decline
- GSE218073 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [LKO_NASH] 10 samples shares mitochondrial, remodeling
- GSE255246 Intrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling 10 samples shares mitochondrial, skeletal
- GSE274492 The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Valid RNA-Seq] 200 samples shares remodeling
- GSE259380 TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody induces tumor regression through profound tumor microenvironment remodeling and strong antitumor adaptive immune response [RNA-seq] 149 samples shares remodeling
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares remodeling
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.