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Smart RNA Sequencing of hepatic Regulatory T Cells from mice with autoimmune hepatitis

GSE284163 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/19 Platform GPL30215
Summary
Autoimmune hepatitis (AIH) is characterized by progressive liver inflammation, often associated with the dysfunction of regulatory T (Treg) cells within the liver microenvironment. To investigate the potential role of Treg dysregulation in AIH progression, we established an AIH mouse model and utilized Foxp3-GFP reporter mice to isolate liver-resident Treg cells through flow cytometric sorting. Subsequently, we performed Smart RNA sequencing to comprehensively profile the transcriptomic landscape of these cells. Our analysis provides novel insights into the molecular mechanisms underlying Treg dysfunction in AIH and offers potential targets for therapeutic intervention.
Published in
Serum amyloid A1-induced intrahepatic regulatory T-cell dysfunction drives autoimmune hepatitis progression
Wang H, Wang S, Lei Y et al. · Hepatology (Baltimore, Md.) 2026 · PMID 40489740 · doi:10.1097/HEP.0000000000001419
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Direct links to NCBI, no account and no request form: the whole study as GSE284163_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1197481 and SRA study SRP551132. Searching any of these in the dataset finder brings you back here.

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