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Sex-dimorphism of TMJOA

GSE284256 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/15 Platform GPL24247
Summary
Temporomandibular joint osteoarthritis (TMJ OA) is a prevalent degenerative disease characterized by chronic pain and impaired jaw function. Similarly to other OA affected limb joints, TMJ OA has shown increased prevalence across several demographic and biological factors. Sex has been considered a risk factor, with female patients reporting twice the incidence rate and suffering from greater symptom severity compared to male patients. However, due to a lack of relevant preclinical models, there is limited knowledge related to how sex differences impact TMJ OA pathophysiology.
Published in
Sex-dependent mechanisms of temporomandibular joint osteoarthritis
Sokolowskei D, James AW, Chu CQ et al. · JBMR plus 2026 · PMID 42110970 · doi:10.1093/jbmrpl/ziag063
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Also filed as BioProject PRJNA1198078 and SRA study SRP551365. Searching any of these in the dataset finder brings you back here.

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