AMPK signaling downstream of adenosine 2A receptor represses Th17 cell pathogenicity through epigenetic and metabolic reprogramming.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 2 × PBS_Input_exp vs 2 × PBS_IP_H3K9ac_exp vs 2 × ActA_Input_exp vs 2 × ActA_IP_H3K9ac_expGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Adenosine 2A receptor-dependent activation of AMPK represses T(H)17 cell pathogenicity through epigenetic and metabolic reprogrammingScience signaling · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284714_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1200091 and SRA study SRP552443. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 15 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8691061 PBS_Input_exp1 PBS_Input_exp
- GSM8691062 PBS_IP_H3K9ac_exp1 PBS_IP_H3K9ac_exp
- GSM8691063 PBS_IP_PCAF_exp1
- GSM8691064 ActA_Input_exp1 ActA_Input_exp
- GSM8691065 ActA_IP_H3K9ac_exp1 ActA_IP_H3K9ac_exp
- GSM8691066 ActA_IP_PCAF_exp1
- GSM8691067 ActA_Dorsomorphin_Input_exp1
- GSM8691068 ActA_Dorsomorphin_IP_H3K9ac_exp1
- GSM8691069 ActA_Dorsomorphin_IP_PCAF_exp1
- GSM8691070 PBS_Input_exp2 PBS_Input_exp
- GSM8691071 PBS_IP_H3K9ac_exp2 PBS_IP_H3K9ac_exp
- GSM8691072 ActA_Input_exp2 ActA_Input_exp
- GSM8691073 ActA_IP_H3K9ac_exp2 ActA_IP_H3K9ac_exp
- GSM8691074 Prkaa1_KO_Input_exp2
- GSM8691075 Prkaa1_KO_IP_H3K9ac_exp2
- GSE286574 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [ATAC-seq] 30 samples shares reprogramming, epigenetic
- GSE294288 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [OSK/OvSvK CUT&TAG] 11 samples shares reprogramming, epigenetic
- GSE294258 Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia 71 samples shares reprogramming, epigenetic
- GSE270509 In vivo CRISPR screen reveals interplay of epigenetic regulators underlies kinetics of hepatobiliary reprogramming [RNA-Seq] 27 samples shares reprogramming, epigenetic
- GSE99296 α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming 18 samples shares reprogramming, epigenetic
- GSE296200 A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis [ATAC-seq] 11 samples shares th17
- GSE290022 Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 64 samples shares ampk
- GSE303699 Autoimmune Disease Risk Gene ANKRD55 Promotes Th17 Effector Function Through Metabolic Modulation [RNA-Seq] 60 samples shares th17
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.