The RNA-binding protein HuR impairs adipose tissue anabolism in pancreatic cancer cachexia
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × Sham vs 5 × PDACGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR InhibitionJournal of cachexia, sarcopenia and muscle · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284803_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1200692. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8693532 Sham_1 Sham
- GSM8693533 Sham_2 Sham
- GSM8693534 Sham_3 Sham
- GSM8693535 Sham_4 Sham
- GSM8693536 Sham_5 Sham
- GSM8693537 PDAC_1 PDAC
- GSM8693538 PDAC_2 PDAC
- GSM8693539 PDAC_3 PDAC
- GSM8693540 PDAC_4 PDAC
- GSM8693541 PDAC_5 PDAC
- GSE285906 Oxaliplatin induces cancer-like cachexia through distinct transcriptional pathways in mouse muscle and adipose depots 23 samples shares cachexia, adipose
- GSE251864 Optimization of a Mouse Model of Pancreatic Cancer to More Closely Simulate the Human Phenotypes of Metastasis and Cachexia 22 samples shares pancreatic, cachexia
- GSE304220 Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes 8 samples shares cachexia, adipose
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares pancreatic, adipose
- GSE266923 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver] 61 samples shares pancreatic, adipose
- GSE266920 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [Adipose] 61 samples shares pancreatic, adipose
- GSE244619 ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis [bulk RNA-seq] 24 samples shares rna-binding, protein
- GSE304391 Global identification of ER stress-regulated RNA binding Proteins in clonal pancreatic beta-cells, reveals an important role for DEAD-box helicase 3 X-linked (DDX3X) in the execution of the Unfolded Protein Response and the determination of cell fate. 12 samples shares pancreatic, protein
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.