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Understanding the effect of milk fat containing diet in the gut epithelial homeostasis.

GSE285229 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/17 Platform GPL24247
Summary
We employed single-cell RNA sequencing using 10X Genomics technology to investigate the effect of milk fat diet on gut homeostasis. We have observed that mice with dextran sodium sulfate (DSS)-induced colitis, when fed a milk fat diet, exhibit less severe disease compared to those on a regular chow diet. To further explore this, we examined immune cells, including T cells, B cells, and myeloid cells, along with epithelial cells, which play a critical role in the development of gut inflammation. Our study reveals that mice on the milk fat diet have improved barrier function and higher secretion of antimicrobial proteins, which is reflected in their transcriptomes.
Published in
The JNK2-microbiome axis modulates gut barrier integrity through microbial acetate
Chongtham C, Biswas T, Kumari N et al. · Gut microbes 2026 · PMID 41949064 · doi:10.1080/19490976.2026.2651962
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Also filed as BioProject PRJNA1202078 and SRA study SRP553493. Searching any of these in the dataset finder brings you back here.

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