Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
DNA methylation · human · 60 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 60 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell linesClinical epigenetics · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285258_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1202113 and SRA study SRP553489. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 60 samples.
How we read this: 18 replicated groups read from 60 sample titles; they account for 60 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8699246 MOLM, Untreated, Normoxia, 72 hour, Rep1 MOLM, Untreated, Normox…
- GSM8699247 MOLM, Azacytidine, Normoxia, 72 hour, Rep3 MOLM, Azacytidine, Norm…
- GSM8699248 MOLM, Untreated, Hypoxia, 72 hour, Rep1 MOLM, Untreated, Hypoxi…
- GSM8699249 MOLM, Untreated, Hypoxia, 72 hour, Rep3 MOLM, Untreated, Hypoxi…
- GSM8699252 HL60, Untreated, Normoxia, 72 hour, Rep1 HL60, Untreated, Normox…
- GSM8699253 HL60, Azacytidine, Normoxia, 72 hour, Rep3 HL60, Azacytidine, Norm…
- GSM8699254 HL60, Untreated, Hypoxia, 72 hour, Rep1 HL60, Untreated, Hypoxi…
- GSM8699256 HL60, Untreated, Hypoxia, 72 hour, Rep3 HL60, Untreated, Hypoxi…
- GSM8699258 MOLM, Decitabine, Normoxia, 72 hour, Rep1 MOLM, Decitabine, Normo…
- GSM8699259 MOLM, Untreated, Hypoxia, 144 hour, Rep1 MOLM, Untreated, Hypoxi…
- GSM8699260 MOLM, Untreated, Hypoxia, 144 hour, Rep3 MOLM, Untreated, Hypoxi…
- GSM8699262 HL60, Decitabine, Normoxia, 72 hour, Rep1 HL60, Decitabine, Normo…
- GSM8699263 HL60, Untreated, Hypoxia, 144 hour, Rep1 HL60, Untreated, Hypoxi…
- GSM8699265 HL60, Untreated, Hypoxia, 144 hour, Rep3 HL60, Untreated, Hypoxi…
- GSM8699267 MOLM, Azacytidine, Normoxia, 72 hour, Rep1 MOLM, Azacytidine, Norm…
- GSM8699268 MOLM, Decitabine, Hypoxia, 144 hour, Rep1 MOLM, Decitabine, Hypox…
- GSM8699269 MOLM, Decitabine, Hypoxia, 144 hour, Rep3 MOLM, Decitabine, Hypox…
- GSM8699271 HL60, Azacytidine, Normoxia, 72 hour, Rep1 HL60, Azacytidine, Norm…
- GSM8699272 HL60, Decitabine, Hypoxia, 144 hour, Rep1 HL60, Decitabine, Hypox…
- GSM8699274 HL60, Decitabine, Hypoxia, 144 hour, Rep3 HL60, Decitabine, Hypox…
- GSM8699276 MOLM, Untreated, Normoxia, 72 hour, Rep2 MOLM, Untreated, Normox…
- GSM8699277 MOLM, Azacytidine, Hypoxia, 144 hour, Rep1 MOLM, Azacytidine, Hypo…
- GSM8699278 MOLM, Azacytidine, Hypoxia, 144 hour, Rep3 MOLM, Azacytidine, Hypo…
- GSM8699280 HL60, Untreated, Normoxia, 72 hour, Rep2 HL60, Untreated, Normox…
- GSM8699281 HL60, Azacytidine, Hypoxia, 144 hour, Rep1 HL60, Azacytidine, Hypo…
- GSM8699283 HL60, Azacytidine, Hypoxia, 144 hour, Rep3 HL60, Azacytidine, Hypo…
- GSM8699285 MOLM, Decitabine, Normoxia, 72 hour, Rep2 MOLM, Decitabine, Normo…
- GSM8699286 MOLM, Untreated, Hypoxia, 72 hour, Rep2 MOLM, Untreated, Hypoxi…
- GSM8699288 HL60, Decitabine, Normoxia, 72 hour, Rep2 HL60, Decitabine, Normo…
- GSM8699289 HL60, Untreated, Hypoxia, 72 hour, Rep2 HL60, Untreated, Hypoxi…
- GSM8699291 MOLM, Azacytidine, Normoxia, 72 hour, Rep2 MOLM, Azacytidine, Norm…
- GSM8699292 MOLM, Untreated, Hypoxia, 144 hour, Rep2 MOLM, Untreated, Hypoxi…
- GSM8699294 HL60, Azacytidine, Normoxia, 72 hour, Rep2 HL60, Azacytidine, Norm…
- GSM8699295 HL60, Untreated, Hypoxia, 144 hour, Rep2 HL60, Untreated, Hypoxi…
- GSM8699297 MOLM, Untreated, Normoxia, 72 hour, Rep3 MOLM, Untreated, Normox…
- GSM8699298 MOLM, Decitabine, Hypoxia, 144 hour, Rep2 MOLM, Decitabine, Hypox…
- GSM8699300 HL60, Untreated, Normoxia, 72 hour, Rep3 HL60, Untreated, Normox…
- GSM8699301 HL60, Decitabine, Hypoxia, 144 hour, Rep2 HL60, Decitabine, Hypox…
- GSM8699303 MOLM, Decitabine, Normoxia, 72 hour, Rep3 MOLM, Decitabine, Normo…
- GSM8699304 MOLM, Azacytidine, Hypoxia, 144 hour, Rep2 MOLM, Azacytidine, Hypo…
+ 20 more — browse all 60 samples with per-sample file links →
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing · shares myeloid, acute
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing · shares myeloid, acute
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares myeloid, acute
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing · shares myeloid, acute
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing
- GSE285257 Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines [RNA-seq] 18 samples shares hla-dr, decitabine-induced, leukaemia, hypoxia, impairs, myeloid, acute, lines
- GSE335296 C1QBP expression and function in acute myeloid leukaemia. 298 samples shares leukaemia, myeloid, acute
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.