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CUT&RUN of 3 months old wild type and hepatocyte-specific ATF6 overexpression mice

GSE285262 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 25 samples 2024/12/28 GPL30172
Summary
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality with limited therapies. While endoplasmic reticulum (ER)-stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR-transducer activating transcription factor 6 alpha (ATF6α) remains unclear. We generated hepatocyte specific n-ATF6 overexpression transgenic mice via Cre-mediated recombination.
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