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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

GSE285466 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/09/05 Platform GPL24676
Summary
We discovered, through untargeted metabolomics, that creatine promotes ferroptosis in colorectal cancer. Our study identifies ERK2 as a creatine sensor that mediates active FSP1 and ferroptosis resistance, and highlights the potential of targeting tumor SLC6A8 for cancer treatment.
Published in
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
Zhou X, Wang G, Wu Y et al. · Cell reports 2025 · PMID 40892544 · doi:10.1016/j.celrep.2025.116139
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Also filed as BioProject PRJNA1203678 and SRA study SRP554138. Searching any of these in the dataset finder brings you back here.

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